The 4800 MALDI TOF/TOF Analyzer Offers New Level of Sensitivity and Efficiency for Proteomics.

New ABI 4800 Mass Spectrometer on-line.

4800 ABI MALDI TOF/TOF Mass Spec
The new instrument achieves a ten-fold increase in sensitivity over existing commercially available systems and offers unparalleled experimental efficiency using powerful, automated workflows, making it an ideal solution for protein biomarker discovery.

ITRAQ - 8 plex isobaric peptide tagging system
SILAC - stable isotope labeling of amino acids in cell culture
GIST - global internal standard technology, a post digestion peptide level labeling technique
ICAT - isotope coded affinity tag-based protein profiling

The 4800 MALDI TOF/TOF(TM) Analyzer combines the Applied Biosystems/MDS SCIEX joint venture's breakthrough TOF/TOF(TM) optics technology with the novel OptiBeam(TM) on-axis laser, which increases the number of ions directed into the ion path to achieve the dramatic increase in sensitivity. Additionally, the enhanced QuanTIS(TM) precursor ion allows users to more specifically isolate the precursor ions designated for MS/MS, thus achieving more accurate and easier-to-interpret results. Proprietary iTRAQ(TM) and ICAT(R) reagents, which are fully compatible with the new 4800 MALDI TOF/TOF(TM) Analyzer, further enable biomarker discovery by permitting relative and absolute protein quantitation. The increased sensitivity and expanded dynamic range of the analyzer yields high-confidence protein identifications, enables multiplex studies with the use of the iTRAQ(TM) reagents, and enables true results-dependent analysis results with or without tagging chemistry, such as ICAT(R) reagents.

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